Application of AI Processes to Non-Grading Molecular Glues: Case studies on GSTP1 & TRAFF2
- Discuss the application of a developed AI process for predicting target vulnerability towards non-degrading molecular glue platforms
- Highlight the ternary crystal structures of molecules bound to GSTP1 where a novel mode of binding is uncovered
- Address the ternary crystal structures of molecules disrupting the PPI of TRAF2, showing a mechanism of PPI inhibition only possible through ternary complex formation